I am a Mac user myself, but the GEDCOM "standard" makes that irrelevant. It serves like RTF (rich text format) to expedit cross platform database exchanges. But "standard" is something that needs to be understood as in quotes. You don't need to know much about the innards of how it works, but here is a complete explanation if you want it.

I can't list everything here, just a few that I either use now or have used. There are some pointers at the bottom to software lists maintained by others. I use Reunion and recommend it with enthusiasm to Mac users.

Software to create and maintain Family Tree databases

Software to convert GED files to web pages

Software to remove "personal information" (for living persons) from GED files

Links to more software